Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
Opioid Receptor Isoform Specific Products
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Opioid Receptor Inhibitors
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Opioid Receptor Agonists
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Opioid Receptor Antagonists
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Opioid Receptor Activators
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Opioid Receptor Modulators
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Opioid Receptor Controls
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Opioid Receptor Ligands
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Opioid Receptor Related Products (614)
Related Products (614)
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Antibodies (3)
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Opioid Receptor Isoform Comparison
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Bisacodyl (Standard)
0 ImagesBisacodyl (Standard) is the analytical standard of Bisacodyl. This product is intended for research and analytical applications. Bisacodyl is a stimulant laxative agent that works directly on the colon to produce a bowel movement. Bisacodyl increases the secretion of PGE2 by direct activation of colon macrophages. PGE2 acts as a paracrine factor and decreases the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect.
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DuP 747 hydrochloride
0 ImagesCat. No.: HY-120045ACAS No.: 115904-74-0DuP 747 hydrochloride is an analgesic with selective kappa-opioid receptor agonist activity. DuP 747 showed less spiradoline-appropriate selection when administered SC, but showed a partial generalized response to spiradoline when administered IP or PO. The 5-hydroxy-desmethoxy metabolite of DuP 747 induced selection of the saline-appropriate lever only. The effects of DuP 747 suggest that its metabolites may play a major role in the similar responses to spiradoline after IP and PO administration.
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CP-866,087
0 ImagesCat. No.: HY-123582CAS No.: 519052-02-9CP-866,087 is a novel, potent and selective μ-opioid receptor antagonist with activity to inhibit opioid effects. CP-866,087 has shown promising preclinical efficacy data in disease models associated with alcohol consumption. CP-866,087 has also been used to study female sexual dysfunction.
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AH 8529
0 ImagesCat. No.: HY-W326260CAS No.: 41805-00-9AH 8529 is an orally active opioid compound. AH 8529 has an analgesic effect.
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O,O-Diethyl dithiophosphate-13C4 ammonium
0 ImagesCat. No.: HY-W778148CAS No.: 1329641-22-6O,O-Diethyl dithiophosphate-13C4 ammonium is the 13C labeled isotope of O,O-Diethyl dithiophosphate ammonium.
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NOP agonist-2
0 ImagesCat. No.: HY-156993CAS No.: 2099680-36-9NOP agonist-2 is a selective NOP agonist.
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Tianeptine sodium salt (Standard)
0 ImagesTianeptine sodium salt (Standard) is the analytical standard of Tianeptine sodium salt (HY-90003A). This product is intended for research and analytical applications. Tianeptine sodium salt is an atypical antidepressant. Tianeptine sodium salt is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR). Tianeptine sodium salt is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine sodium salt increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine sodium salt exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine sodium salt inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine sodium salt can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.
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N-(1-Benzyl-4-piperidyl)-N-benzylpropanamide hydrochloride
0 ImagesCat. No.: HY-168826CAS No.: 117994-42-0N-(1-Benzyl-4-piperidyl)-N-benzylpropanamide hydrochloride is structurally similar to known opioids.
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2,4-Difluoro U-48800 hydrochloride
0 ImagesCat. No.: HY-165001CAS No.: 2740304-36-12,4-Difluoro U-48800 hydrochloride is a utopioid.
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Nalmefene (Standard)
0 ImagesCat. No.: HY-107744RCAS No.: 55096-26-9Nalmefene (Standard) is the analytical standard of Nalmefene. This product is intended for research and analytical applications. Nalmefene is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene is used for opioid overdose and alcohol dependence.
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Methylketobemidone
0 ImagesCat. No.: HY-168815CAS No.: 64058-44-2Methylketobemidone is structurally similar to known opioids.
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3,4-Difluoro U-50488 hydrochloride
0 ImagesCat. No.: HY-139390CAS No.: 1339332-99-83,4-Difluoro U-50488 hydrochloride is a utopioid.
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Hodgkinsine B
0 ImagesCat. No.: HY-N12180CAS No.: 586955-76-2Hodgkinsine B is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine B has antiviral, antibacterial and antifungal activities.
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Alvimopan (Standard)
0 ImagesCat. No.: HY-13243RCAS No.: 156053-89-3Synonyms: ADL 8-2698 (Standard); LY 246736 (Standard)Alvimopan (Standard) is the analytical standard of Alvimopan. This product is intended for research and analytical applications. Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus.
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2-Naphthyl U-47700
0 ImagesCat. No.: HY-168820CAS No.: 67579-80-02-Naphthyl U-47700 is a utopioid.
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AH 8507
0 ImagesCat. No.: HY-W714509CAS No.: 41805-63-4AH 8507 structurally belongs to the opioid compounds and is an analog of AH 7563 (HY-W714505). However, AH 8507 does not exhibit significant analgesic effects in mice in both the phenylquinone test and the hot plate test, with ED50 values greater than 100 mg/kg.
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3,4-Difluoro propyl U-47700
0 ImagesCat. No.: HY-165021CAS No.: 2741276-45-73,4-Difluoro propyl U-47700 is a utopioid.
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Trimebutine (Standard)
0 ImagesTrimebutine (Standard) is the analytical standard of Trimebutine (HY-B0380). This product is intended for research and analytical applications. Trimebutine is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).
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JDTic dihydrochloride (Standard)
0 ImagesCat. No.: HY-10487RCAS No.: 785835-79-2JDTic dihydrochloride (Standard) is the analytical standard of JDTic dihydrochloride (HY-10487). This product is intended for research and analytical applications. JDTic dihydrochloride is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
